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Top Travel Destinations in South America

With its vast landscapes, rich cultures, and diversity of activities, South America offers adventures and experiences like no other continent. Here are some of the top destinations to consider for your next South American getaway:

Top Airlines Flying from USA to South America
New York sorting-arrows-horizontal--v2 Rio de Janeiro
From $649*
Washington DC sorting-arrows-horizontal--v2 Santiago
From $869*
Chicago sorting-arrows-horizontal--v2 Sao Paulo
From $629*
Atlanta sorting-arrows-horizontal--v2 Cusco
From $649*
Dallas sorting-arrows-horizontal--v2 Buenos Aires
From $639*
San Francisco sorting-arrows-horizontal--v2 Cusco
From $589*
Las Vegas sorting-arrows-horizontal--v2 Mar del Plata
From $699*
Los Angeles sorting-arrows-horizontal--v2 Arequipa
From $859*
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Direct flights deals from USA to South America
Seattle sorting-arrows-horizontal--v2 South America

DLDec 29, 2023

2 Stops

Dallas sorting-arrows-horizontal--v2 South America

DLDec 26, 2023

2 Stops

Atlanta sorting-arrows-horizontal--v2 South America

DLDec 20, 2023

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Last minutes flight deals from USA to South America
Atlanta sorting-arrows-horizontal--v2 South America

DLDec 28, 2023

2 Stops

Chicago sorting-arrows-horizontal--v2 South America

DLJan 29, 2024

2 Stops

Las Vegas sorting-arrows-horizontal--v2 South America

DLDec 22, 2023

2 Stops

Atlanta sorting-arrows-horizontal--v2 South America

DLJan 15, 2023

2 Stops

Los Angeles sorting-arrows-horizontal--v2 South America

DLJan 23, 2023

2 Stops

Miami sorting-arrows-horizontal--v2 South America

LXJan 20, 2024

2 Stops

Denver sorting-arrows-horizontal--v2 South America

DLJan 15, 2023

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Seattle sorting-arrows-horizontal--v2 South America

LXJan 08, 2023

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Boston sorting-arrows-horizontal--v2 South America

SQJan 19, 2023

2 Stops


Your trip to Latin America is complete without a visit to vibrant Brazil. Rio de Janeiro and its beautiful beaches of Copacabana and Ipanema should be at the top of your list to soak up the sun, sea, and beach. March through May are ideal times to visit Rio to experience sunny weather without the rain and crowds of summer.

For a cosmopolitan city getaway, São Paulo offers world-class dining, nightlife, and arts scenes best enjoyed from April through August. Nature lovers must visit the natural wonder of Iguazu Falls on the border of Brazil and Argentina. Head there from February to May for mild temperatures without rainfall.

Most major airlines like American Airlines, Delta Airlines, and United Airlines offer non-stop flights from major U.S. cities to Rio de Janeiro and São Paulo. For travel within Brazil, Gol and Azul are reliable domestic carriers.


Home to tango, grilled steaks, and European influences, Argentina captures the essence of South America. Top destinations include lively Buenos Aires, best visited April through June when temperatures are mild; beautiful Patagonia and glacial landscapes like Perito Moreno Glacier, best seen December through March when chances of sunshine are highest; and vibrant Mendoza, the heart of Argentine wine country, with March through May offering warm days and grape harvests.

Most major U.S. airlines like American and Delta fly directly to Buenos Aires, while LATAM is a top domestic carrier. International carriers like Air France and Iberia also offer connecting flights from European hubs.


From the Atacama Desert to Patagonia, Chile offers epic natural scenery. Nature lovers shouldn’t miss Torres del Paine National Park, best visited from December to February during the Southern Hemisphere summer when the weather is warmest.

You can head to laidback Puerto Varas on Lake Llanquihue from December to March. And Vibrant Santiago from October through December when spring weather is pleasant. Top domestic carriers include LATAM and Sky Airline.

Major international carriers like American Airlines, Delta, and United provide non-stop flights from the U.S. to Santiago, while LATAM operates connecting flights throughout South America.


Peru is home to the enigmatic Inca ruins of Machu Picchu and vibrant cultures. Peru is a must-visit. Outside of the rainy season from December to April, the top times to visit include May, June, September, and October. Don’t miss Machu Picchu, best accessed from April to October via train from Cusco. Lima offers culinary delights year-round but is especially pleasant from May through September. LATAM offers reliable domestic flights throughout Peru.

Major international carriers like American, Delta, and United provide direct flights to Lima from the U.S., with connecting options on LATAM throughout South America. For Machu Picchu, book in advance due to limited visitor capacity.

Whichever South American destinations you choose, planning for weather patterns, travel seasons, and transportation options will help you maximize your experience. Let me know if you need any other trip-planning recommendations for creating lasting memories.

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Frequently Asked Questions

Can I island-hop in Hawaii?

The CDC recommends routine vaccines for travel to South America and other additional vaccines depending on destinations. Check the CDC website for up-to-date vaccine recommendations by country.

What is the currency?

Countries in South America use currencies like the Brazilian Real, Argentine Peso, Chilean Peso, and Peruvian Sol. US dollars in major cities and tourist areas, but local currencies offer better rates. Always carry some cash in small denominations for tips, taxis, and other incidentals.

Which airlines operate flights to South America?

Many international carriers like American Airlines, Delta Airlines, United Airlines LATAM, COPA Airlines, and Avianca Airlines operate flights from the USA to major cities in Latin America.

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